Supersensitivity of amylase secretion by isoproterenol from rat parotid glands treated briefly with the agonist.
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چکیده
منابع مشابه
Amylase mRNA synthesis and ageing in rat parotid glands following isoproterenol-stimulated secretion.
In the parotid, as well as in other exocrine glands, secretory protein synthesis declines with age. However, whether this decline in the steady-state rate of protein synthesis reflects the reduced digestive activity of the animal or actual cellular alterations that affect synthesis is unknown. Here the ability to synthesize amylase and its mRNA during the period of enhanced protein synthesis fo...
متن کاملProtein synthesis and amylase messenger RNA content in rat parotid salivary glands after total or partial stimulation with isoproterenol.
The rate of synthesis of secretory proteins increases significantly in rat parotid glands after stimulated discharge of stored proteins. How any difference in the amount of secretory protein discharge affects the rate of subsequent protein synthesis, and whether this post-secretory synthesis is regulated at the level of messenger RNA, was now examined. One group of rats was stimulated to secret...
متن کاملInhibitory effect of colchicines on amylase secretion by rat parotid glands: possible localization in the golgi area
Colchicine inhibited amylase secretion by isolated rat parotid glands only 6 h after administration of the drug in vivo. This delayed effect was not the result of the inability of the drug to reach its reaction site. When parotid glands were emptied of their secretory granules by isoproterenol treatment, the subsequent replenishment of cells with granules was inhibited by colchicines. Colchicin...
متن کاملProperties of proline-rich proteins from parotid glands of isoproterenol-treated rats.
This report describes the physical and chemical properties of a series of proline-rich proteins isolated from parotid glands of isoproterenol-treated rats. As described previously (Muenzer, J., Bildstein, C., Gleason, M., and Carlson, D. M. (1979) J. Biol. Chem. 254, 56235628), a dramatic increase in these proteins occurs concomitantly with hyperplasia and hypertrophy of parotid glands of rats ...
متن کاملPurification of proline-rich proteins from parotid glands of isoproterenol-treated rats.
Prolonged isoproterenol treatment of rats is known to cause hypertrophy and hyperplasia of the parotid glands. Our results show that a dramatic increase in the synthesis or accumulation in the parotid glands of a series of proteins rich in proline also occurs with isoproterenol treatment. After 10 days of treatment (5 mg of isoproterenol/day) these proline-rich proteins (PRPs) comprise more tha...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1993
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)51164-7